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Rashmi Kaul, Ph.D.Rashmi Kaul, Ph.D.
Associate Professor of Immunology


Instructional Activities | Research Interests | Extramural Funding | Publications

Instructional Activities

  • Medical Microbiology and Immunology- MS I (lectures in Medical Immunology)

Research Interests

  1. Role of hormones and complement regulatory proteins in the development of Hepatic carcinoma.
  2. Study of disease pathogenesis in animal models of human disease.
    1. To study the role of cytokines in urinary tract infection induced preterm labor mouse model.
    2. Development of mouse model for Bacterial Cholangitis.

Extramural Funding

The pathogenesis of E.coli induced cholangitis - University of Minnesota, Grant-in-Aid of Research, Artistry and Scholarship (Principal Investigator)

Isolation of Human Pathological Hepatocytes for Liver Tissue Procurement and Distribution System Contract - Minnesota Medical Foundation (Principal Investigator)

Molecular Mechanisms of IL-10 and TNF-alpha in Regulation of Apoptosis of Bile Duct Cells - Minnesota Medical Foundation - (Principal Investigator)

Role of Cytokines in Bile Duct Cell Injury and Protection in Vitro - Viking Children's Fund (Principal Investigator)

Immune Mechanisms Involved in Chronic Pyelonephritis - National Kidney Foundation (Principal Investigator)

Bacterial Lectin in the Diagnosis & Follow-up of Endometrial Hyperplasia - American Cancer Society (Co-Investigator)

Effect of Hormones on Complement Regulatory Proteins in Breast Cancer - Susan G Komen Race for Cure Breast Cancer Foundation (Co-Investigator)

Regulation of Experimental Myasthenia Gravis by CD8 positive T-cells - Myasthenia Gravis Foundation (Principal Investigator)

Transfer of Rheumatoid Arthritis like lesions into SCID mice - James W. McLaughlin Fellowship Fund (Principal Investigator)

Representative Publications & Presentations

Singh, G., Kaul, R., Khan, W., and Malaviya, A.N. Can Nifedipine provoke menorrhagia? The Lancet 1022. October 29, 1983.

Malaviya, A.N., Banerjee, S., Misra, R.N., Kaul, R., and Bhuyan, U.N. Antinuclear factor and rheumatoid factor estimations in the diagnosis of rheumatic diseases in North India. Asian Pacific Journal of Allergy & Immunology 2:232-236, 1984.

Gupta, R., Malaviya, A.N., Kaul, R., Kumar, A., Mehra, N.K., and Kumar S. Gut flora in HLA-B27-related reactive anthropathy. J. Asso. Physicians of India 34:310-315, 1986.

Shenoy, M., Wu, Bo, Kaul, R., Goluszko, E., David, C. and Christadoss, P. Possible linkage of myasthenia gravis susceptibility in RIII/SJ mice to the genomic deletion of chromosomal segment coding the T cell receptor Vbeta In: Autoimmunity: Experimental Aspects. (Ed: M. Zouali) pp 213-230, Springer Verlag, Heidelberg, 1994.

Kaul, R., M. Shenoy, E. Goluszko and P. Christadoss. Major histocompatibility complex class II gene disruption prevents autoimmune myasthenia gravis. J. Immunol. 152:3152-3157, 1994.

Christadoss P, Kaul R., Shenoy M, Goluszko E. Establishment of a mouse model of myasthenia gravis which mimics human myasthenia gravis pathogenesis for immune intervention. Adv Exp Med Biol. 383:195-9, 1995.

Shenoy, M., Kaul, R.,Goluszko, E., Davis, C.S.,and Christadoss. MHC class I restricted CD8+ T cells are not the effectors during the induction of autoimmune myasthenia gravis in C57BL10 mice. J. Immunol., 152:5330-5335,1994.

Kaul, R., Shenoy, M., and Christadoss, P. The role of major histocompatibility complex genes in myasthenia gravis and experimental autoimmune myasthenia gravis pathogenesis. Advances in Neuroimmunology, 4:387-402, 1994.

Kaul, R., Sharma, A., Lisse, J.R., and Christadoss, P. Effect of recombinant human IL-2 in the induction of RF production and generating inflammatory synovitis in SCID mice engrafted with PBMC from RA patients with active disease. Clin.Immunol & Immunopath. 74:271-282,1995.

Wu B, Shenoy M, Goluszko E, Kaul R. and Christadoss P. TCR gene usage in experimental autoimmune myasthenia gravis pathogenesis: Usage of multiple TCR Vbeta gene in the H-2b strains. J. Immunol.154:3603-10, 1995.

Kaul R., WuBo, Goluszko E and Christadoss P. Experimental autoimmune myasthenia gravis induction in B10.BV8S2 transgenic mice: Preferential usage of TCR AV1 gene by lymphocytes responding to acetylcholine receptor. J Immunol. 158(12): 6006-12,1997.

Kaul R., Martens M, Khan S, Crosson J, Kaul A. Development of a human endometriosis model in SCID-beige mice. J Soc Gynecol Invest 6: 220A, 1999.

Kaul, A., Khan, S., Martens, M., Crosson, J., Lupo, V., Kaul, R. Experimental gestational pyelonephritis induced preterm birth and low birth weight in C3H/HeJ mice. Infect Immun 67(11): 5958-66, 1999.

Murray K.P, Mathure S, Kaul R., Khan S, Carson L, Twiggs LB, Martens M, Kaul A. Expression of complement regulatory proteins: CD35, CD46, CD55 and CD59; In benign and malignant endometrium. Gynecol Oncol. 76; 176-82, 2000.

Kimura Y, Leung PSC, Kenny TP, Van De Water J, Nishioka M, Giraud AS, Neuberger J, Benson G, Kaul R., Ansari AA, Coppel RL, Gershwin ME. Differential expression of intestinal trefoil factor (ITF) in biliary epithelial cells of primary biliary cirrhosis. Hepatology. 36:1227-35, 2002.

Kim JW, Ye Q, Forgues M, Chen Y, Budhu A, Sime J, Hofseth LJ, Kaul R., Wang XW. Cancer-associated molecular signature in the tissue samples of patients with cirrhosis. Hepatology .39(2): 18-27, 2004.