Education
1992
Ph.D. (Microbiology)
TU München
Munich, Germany
1989
M.S. (Biology)
TU München
Munich, Germany
Professional Experience
2007-Present
Assistant Professor of Microbiology, Center for Health Sciences, Department of Biochemistry and Microbiology
2001-2007
Assistant Researcher, Department of Cell and Tissue Biology, University of California, San Francisco (UCSF)
1995-2000
Staff Scientist, Research Center for Infectious Diseases, University of Würzburg, Germany
1992-1995
Postdoctoral Fellow, Intercampus Program of Molecular Parasitology, UCSF
Instructional Activities
Medical Microbiology and Immunology
Research Interests
Fungal pathogenesis: Role of lipid metabolism and lipid mediators in fungal infections.
Microbiota-host-pathogen relationship: Elucidation of molecular interactions of beneficial microorganisms with the host and (fungal) pathogens.
Current Extramural Funding
NIH/NIAID “PGE2 Biosynthesis in Candida albicans”2007 - 2009
Representative Publications
Sroussi, H.Y., Köhler, G.A., Agabian, N., Villines, D., and Palefsky, J.M. 2009. Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. FEMS immunology and medical microbiology 55: 55-61.
Köhler, G. A., A. Brenot, E. Haas-Stapleton, N. Agabian, R. Deva, and S. Nigam. 2006. Phospholipase A2 and phospholipase B activities in fungi. BBA – Molecular and Cell Biology of Lipids, 1761: 1391-1399.
Bader, T., K. Schröppel, S. Bentink, N. Agabian, G. Köhler, and J. Morschhäuser. 2006. Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infection & Immunity 74: 4366-4369.
Theiss, S., G. Ishdorj, A. Brenot, M. Kretschmar, C.-Y. Lan, T. Nichterlein, J. Hacker, S. Nigam, N. Agabian, and G. A. Köhler. 2006. Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence. International Journal of Medical Microbiology 296: 405-420.
Reid, G., S. O. Kim, and G. A. Köhler. 2006. Selection, testing and understanding probiotic microbes. FEMS Immunology & Medical Microbiology 46(2): 149-57.
Köhler, G. A., A. Kuo, G. Newport, and N. Agabian. 2006. Genomics of pathogenic fungi p. 389-416. In: J. Hacker and U. Dobrindt (eds.), Pathogenomics – Genome analysis of pathogenic microbes. Wiley-VCH, Weinheim, Germany.
Braun, B. R., M. van het Hoog, C. d’Enfert, M. Martchenko, J. Dungan, A. Kuo, D. O. Inglis, M. A. Uhl, H. Hogues, M. Berriman, M. Lorenz, A. Levitin, U. Oberholzer, C. Bachewich, D. Harcus, A. Marcil, D. Dignard, T. Iouk, R. Zito, L. Frangeul, F. Tekaia, K. Rutherford, E. Wang, C. A. Munro, S. Bates, N. A. Gow, L. L. Hoyer, G. Köhler, J. Morschhäuser, G. Newport, S. Znaidi, M. Raymond, B. Turcotte, G. Sherlock, M. Costanzo, J. Ihmels, J. Berman, D. Sanglard, N. Agabian, A. P. Mitchell, A. D. Johnson, M. Whiteway, and A. Nantel. 2005. A Human-Curated Annotation of the Candida albicans Genome. PLoS Genetics 1: 36-57 (e1).
Morschhäuser, J., P. Staib, and G. Köhler. 2005. CARE-2 Fingerprinting of Candida albicans Isolates, p. 27-34. In E. J. Ernst and P. D. Rogers (ed.), Methods in Molecular Medicine, vol. 118: Antifungal Agents. Humana Press Inc., Totowa, NJ.
Morschhäuser, J., P. Staib, and G. Köhler. 2005. Targeted gene deletion in Candida albicans wild-type strains by MPAR-flipping, p. 35-43. In E. J. Ernst and P. D. Rogers (ed.), Methods in Molecular Medicine, vol. 118: Antifungal Agents. Humana Press Inc., Totowa, NJ.
Köhler, G. A., X. Gong, S. Bentink, S. Theiss, G. M. Pagani, N. Agabian, and L. Hedstrom. 2005. The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. J. Biol. Chem. 280: 11295–11302.
Theiss, S., M. Kretschmar, T. Nichterlein, H. Hof, N. Agabian, J. Hacker, and G. A. Köhler. 2002. Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence. Molecular Microbiology 43: 571-584.
Theiss, S., G. A. Köhler, M. Kretschmar, T. Nichterlein, and J. Hacker. 2002. New molecular methods to study gene functions in Candida albicans. Mycoses 45: 345-350.
Köhler, G., J. Morschhäuser, and J. Hacker. 2002. Genome structure of pathogenic fungi. Curr Top Microbiol Immunol., 264(II): 149-166.
Wirsching, S., S. Michel, G. Köhler and J. Morschhäuser. 2000. Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor. J. Bacteriol., 182: 400-404.
Staib, P., S. Michel, G. Köhler and J. Morschhäuser. 2000. A molecular genetic system for the pathogenic yeast Candida dubliniensis. Gene 242: 393-398.
Staib, P., M. Kretschmar, T. Nichterlein, G. Köhler, and J. Morschhäuser. 2000. Expression of virulence genes in Candida albicans. Adv Exp Med Biol., 485:167-76.
Morschhäuser, J., G. Köhler, W. Ziebuhr, G. Blum-Oehler, U. Dobrindt, and J. Hacker. 2000. Evolution of microbial pathogens. Philos Trans R Soc Lond B Biol Sci. 355(1397):695-704.
Staib, P., M. Kretschmer, T. Nichterlein, G. Köhler, S. Michel, H. Hof, J. Hacker, and J. Morschhäuser. 1999. Host-induced, stage-specific virulence gene activation in Candida albicans during infection. Molecular Microbiology 32: 533-546.
Hacker, J., G. Köhler, and J. Morschhäuser. 1999. Virulence and resistance mechanisms of pathogenic fungi. Nova Acta Leopoldina 307: 151-161.
Müller, F.-M., J. Morschhäuser, G. Köhler, T. Oelschlaeger, S. Khan und J. Hacker. 1999. Adhärenz und Invasion: Zwei Pathomechanismen. Mycoses 42 (Suppl. 1): 39-42.
Hacker, J., G. Blum, G. Köhler, J. Morschhäuser, I. Mühldorfer, and W. Ziebuhr. 1998. Molecular analysis of infectious diseases: Fungal and bacterial infections of the urinary tract. In: I. Nagataki (ed.). Proceedings of the Siebold Memorial International Symposium.
Köhler, G. A., T. C. White, and N. Agabian. 1997. Overexpression of a cloned IMP dehydrogenase of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J. Bacteriol. 179: 2331-2338.
Hacker, J., G. Köhler, A. Lischewski, J. Morschhäuser. 1996. Was können molekulare Methoden in der Mykologie leisten? Med. Report 20: 8-9.
Morschhäuser, J., G. Köhler, and J. Hacker. 1996. Gibt es Pathogenitätsfaktoren bei Pilzen? Mycoses 39(Suppl. 1): 51-54.
White, T. C., G. A. Köhler, S. H. Miyasaki, and N. Agabian. 1995. Expression of virulence factors in Candida albicans. Canadian J. Bot. 73: S1058-S1064.
Agabian, N., S. H. Miyasaki, G. Köhler, and T. C. White. 1994. Candidiasis and HIV infection: virulence as an adaptive response. In: Greenspan, J., (ed). Oral manifestations of HIV infection. Quintessence Publishing C., Carol Stream, Illinois, pp. 65-72.
Gerwald A. Köhler, Ph.D.