Research Interests
Mechanisms involved in the trafficking and targeting of muscarinic acetylcholine receptors.
Representative Publications & Presentations
Olsen, R.W. and Sawyer, G.W. GABAA receptor proteins. Encyclopedia of Biological Chemistry. W.J. Lennarz and M.D. Lane, eds. Elsevier, Oxford, Vol. 2., pp 162-166
Sawyer, G.W., Chiara, D.C., Olsen, R.W., Cohen, J.B. Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513. Journal of Biological Chemistry. 277(51):50036-45,2002.
Nymann-Andersen, J., Sawyer, G.W., Olsen, R.W. Interaction between GABAA receptor subunit intracellular loops: Implications for higher order complex formation. Journal of Neurochemistry. 83(5):1164-71,2002.
Ehlert, F.J., Ansari, K.Z., Shehnaz, D., Sawyer, G.W., and Griffin, M.T. Acetylcholine-induced desensitization of the muscarinic contractile response in guinea pig ileum is inhibited by pertussis toxin-treatment. J. Pharmacol. Ex. Ther ., 299: 1126-1132, 2001.
Sawyer, G.W., Lambrecht, G. and Ehlert, F.J. 2000. Functional role of muscarinic M2 receptors in a a,b-methylene ATP-induced, neurogenic contracts in guinea pig ileum. Br. J. Pharmacol. 129:1458-1464.
Sawyer, G.W. and Ehlert, F.J. 1999. M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: Evidence for M2/M3 receptor interactions. J. Pharmacol. Exp. Ther. 289:464-476.
Ehlert, F.J., Griffin, M.T., Sawyer, G.W., and Bailon, R. 1999. A simple method for estimations of agonist activity at receptor subtypes: Comparison of native and cloned M3 muscarinic receptors in guinea pig ileum and transfected cells. J. Pharmacol. Exp. Ther. 289:981-992.
Ehlert, F.J., Sawyer, G.W. and Esqueda, E.E. 1999. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. Life Sci. 64:387-394.
Sawyer, G. and Ehlert, F. 1999. Pertussis toxin increases isoproterenol-induced relaxation in field-stimulated ileum. European J. Pharmacol. 367:81-84.
Sawyer, G.W. and Ehlert, F.J. 1998. Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon. J. Pharmacol. Exp. Ther. 284:269-277.
Ehlert, F.J., Ostrom, R.S. and Sawyer, G.W. 1997. Subtypes of the muscarinic receptor in smooth muscle. Life Sci. 61:1729-1740.
