Alexander Rouch, Ph.D.
Chair, Department of Pharmacology & Physiology
Associate Professor of Physiology
Education | Professional Experience | Service & Contributions | Professional Societies | Extramural Funding | Publications | Recreational Interests | Instructional Activities | Research Interests | Biographical Information
Medical College of Georgia
M.S. (Life Sciences)
University of Tennessee
United States Military Academy
West Point, NY
Nephrology Research and Training Center
University of Alabama at Birmingham
Associate Professor of Physiology, Oklahoma State University College of Osteopathic Medicine (OSU-COM), Tulsa, OK
Assistant Professor of Physiology, OSU-COM
Effect of nerves on kidney function, National Science Foundation, $150,000
Effect of lumen pH on sodium and potassium transport in the collecting duct. OCAST, $53,208
Refereed Jounal Articles
Schafer, J.A., L. Chen, C.T. Hawk, L. Kudo, and A.J. Rouch. Synergism of vasopressin and aldosterone actions Na+ transport in the rat cortical collecting duct. Aldosterone: Fundamental Aspects. 215: 219-228, 1991.
Schafer, J.A., L. Chen, and A.J. Rouch. The role of vasopressin in the regulation of Na+ and K+ transport in the cortical collecting duct. Vasopressin. 208: 493-501, 1991. (Proc. Third Internat. Congress on Vasopressin, Montpellier, France).
Rouch, A.J., S.L. Troutman, L. Chen, and J.A. Schafer. Na+ transport in rat CCD: Effects of bradykinin, ANP, hydrochlorothiazide, and clonidine. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29): F86-F95 1991.
Rouch, A.J., G.M. Whitford, and H.T. Campbell. Fluoride flux in the rabbit CCD: A pH-dependent event. Kidney International.41: 342-349, 1992.
Hawk, C.T., L.H. Kudo, A.J. Rouch, and J.A. Schafer. Inhibition by epinephrine of AVP-and cAMP-stimulated Na+ and water transport in Dahl rat CCD. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 34): F449-F460, 1993.
Rouch, A.J., L. Chen, L.H. Kudo, P.D. Bell, B.C. Fowler, B.D. Corbitt, and J.A. Schafer. Intracellular Ca2+ and PKC activation do not inhibit Na+ and water transport in rat CCD. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol. 34): F569-F577, 1993.
Rouch, A.J. and L.H. Kudo. a2-Adrenergic-mediated inhibition of water and urea permeability in the rat IMCD. Am. J. Physiol. 271 (Renal Fluid and Electrolyte Physiol. 40): F150-F157,1996.
Rouch, A.J., L.H. Kudo, and C.A. Hébert. Dexmedetomidine inhibits osmotic water permeability in the rat cortical collecting duct. J. Pharmacol. Exp. Ther. 281: 62-69, 1997.
Rouch, A.J. and L.H. Kudo. Indomethacin and staurosporine reverse a2 inhibition of water transport in rat IMCD. Kidney International. 52: 1351-1358, 1997.
Rouch, A.J., C.A. Hébert, and L.H. Kudo. Inhibition of water permeability in the rat collecting duct: effect of imidazoline and alpha-2 compounds. Proc. Soc. Exp. Biol. Med. 221:136-146, 1999.
Rouch, A.J. and L.H. Kudo. Role of PGE2 in a2-induced inhibition of AVP- and cAMP-stimulated H2O, Na+ and urea transport in the rat IMCD. Am J Physiol. Renal. 279: F294-F301, 2000.
Rouch, A.J. Hormonal Effects on Urinary Acidification. In Handbook of Endocrinology, 2nd ed., ed. by G.H. Gass and H.M. Kaplan, pp. 67-79, CRC Press, 1996.
Rouch, A.J. Mecanismos de Acidificação Urinária. In Princípios de Nefrologia e Distúrbios Hidroelectrolíticos, 3rd ed., ed. by M. C. Riella, pp. 39-43, 1996.
Sex differences in the renal regulation of sodium handling and blood pressure
My primary interest is in how the female and male kidneys differ in structure and function. Premenopausal women are protected from numerous kidney diseases compared to age-matched males and this protection is lost after menopause. The sex hormones estrogen and testosterone have important roles in the sex differences related to the kidney. My studies focus on the renal regulation of sodium transport and blood pressure. I measure these parameters in female and male mice upon consuming normal and high-salt diets. Studies are conducted in normal mice and gonadectomized mice supplemented with either estrogen or testosterone. The objectives are to determine the physiological and molecular mechanisms of estrogen and testosterone on renal sodium handling and correlate these effects with changes in blood pressure. I am also interested in analyzing the transcriptomes of female and male kidneys under these various conditions using the technique of serial analysis of gene expression.
I joined the university in June 1992 as an Assistant Professor in Physiology. As a faculty member I am responsible for teaching, research, and service. Teaching physiology to medical students requires not only presenting the fundamentals of the physiological systems (neural, cardiovascular, renal, gastrointestinal, respiratory, and endocrine) but also enabling the students to integrate the systems in such a way that develops a full understanding of how the human body functions. Research requires an active participation in the discovery of new knowledge and sharing that knowledge with colleagues, students, and the community. Service requires participating on university committees and taking an active role in developing appropriate policies for the college.