Education
1992-1996
Postdoctoral Fellow (Pharmacology)
University of Kentucky
Lexington, KY
1990-1992
Postdoctoral Fellow (Pharmacology)
University of Colorado Health Science Center
Denver, CO
1991
Ph.D. (Pharmaceutical Science)
University of Florida
Gainesville, FL
1984
B.S. (Biomedical Science)
Western Michigan University
Kalamazoo, MI
Professional Experience
2007-present
Professor of Pharmacology, OSU-CHS
2005-present
Adjunct Associate Professor, Toxicology,
OSU Veternary Health Science Center, Stillwater, OK
2004-present
Associate Professor, Forensic Science,
OSU Center for Health Sciences (OSU-CHS), Tulsa, OK
2001-2007
Associate Professor, Pharmacology & Physiology,
OSU-CHS
1997-2001
Adjunct Assistant Professor,
Health Sciences and Nursing Education,
Rogers State University, Claremore, OK
1996-2001
Assistant Professor, Pharmacology & Physiology,
OSU-CHS
Service & Contribution
- Chair, Research Committee, OSU-CHS, 2005-2006
- Past-President, Faculty Senate, OSU-CHS, 2005-2006
- President, Faculty Senate, OSU-CHS, 2004-2005
- Vice-Chair, Biomedical Science Section of the Oklahoma Academy of Sciences, 2003-2004
- President-Elect, Faculty Senate, OSU-CHS, 2003-2004
- Member, Institutional Animal Use and Care Committee, OSU-CHS, 2002-2003
- Secretary, Faculty Senate, OSU-CHS, 2002-2003
- Member, Faculty Senate, OSU-CHS, 2001-2003
- Member, Biomedical Science Graduate Committee, OSU-CHS, 2001-present
- Member, Hazardous Materials and Equipment Committee, OSU-CHS, 2001-present
- Member, Budget and Benefits Committee, OSU-CHS, 2001-2002
- Chair, Research Committee, OSU-CHS, 2001-present
- Member, Pharmacology Faculty Search Committee, OSU-CHS, 2000-2001
- Chair, Biomedical Science Section of the Oklahoma Academy of Sciences, 2000-2003
- Secretary, Faculty Senate, OSU-CHS, 2000-2001
- Member, Institutional Review Board, OSU-CHS, 2000-2002
- Vice-Chair, Biomedical Science Section of the Oklahoma Academy of Sciences, 1999-2000
- Coordinator, Biomedical Science Seminar Series, OSU-CHS, 1999-2000
- Sargent-At-Arms, Faculty Senate, OSU-CHS, 1999-2000
- Member, Physiology Faculty Search Committee, OSU-CHS, 1998-1999
- Member, Radiation Safety Committee, OSU-CHS, 1998-present
- Member, Research Committee, OSU-CHS, 1997-2001
- Member, Curriculum Committee, OSU-CHS, 1997-2000
- Member, Pharmacology Faculty Search Committee, OSU-CHS, 1997
- Reviewer, “Biomedical Sciences Section”, Oklahoma Academy of Sciences, 1996-1997
- Consultant, Williams and Associates, Memphis, TN, 1993
Professional Societies
- Society for Neuroscience
- International Brain Research Organization
- American Society for Neurochemistry
- American Society for Pharmacology and Experimental Therapeutics
- Experimental Biology
- Oklahoma Academy of Science
- International Society for Neurotoxicology
Extramural Funding
Current Funding:
- HIV/Cocaine Neurotoxicity in Females, NIH/NIDA DA13137, $240,000, 2005-2010
Previous Funding:
- Characterization of the D3-preferring agonist, pramipexole in rat striatum and nucleus accumbens, Pharmacia-Upjohn, $6,000, 1996-1997
- Functional Evolution of Opioid Receptors, NIH/NIDA DA12448 (Co-Investigator, 5% effort), $75,000, 1999-2000
- Delta Opioid Attenuation of Oxidative Stress in SK-N-SH cells., American Society of Pharmacology and Experimental Therapeutics (ASPET), SURF Award, $2,500, 2001
- Gender Differences in gp120 and Tat Neurotoxicity, BRIN Undergraduate Fellowship, $1,500, 2003
- Functional Evolution of Opioid Receptors NIH/NIDA DA12448, (Co-Investigator, 5% effort), $146,500, 2002-2003
- Gender differences in gp120 and Tat neurotoxicity, Oklahoma EPScoR BRIN fellowship, $1,500, 2003
Representative Publications & Presentations
(Most recent of 42)
R. Dawson Jr. and D.R. Wallace. (1990). Neural renal interactions in the hypertension induced by papillary necrosis: Role of dietary NaCl intake. Pharmacol., 40:42-53.
R. Dawson Jr. and D.R. Wallace, and M.J. King. (1990). Monoamine and amino acid content in brain regions of the Brattleboro rat. Neurochem. Res., 15:755-761.
D.R. Wallace and R. Dawson Jr. (1990). Decreased plasma taurine content in aged rats. Gerontol., 36:19-27.
R.J. Ulshafer, D.M. Sherry, R. Dawson Jr., and D.R. Wallace. (1990). Excitatory amino acid involvement in retinal degeneration. Brain Res., 531:350-354.
D.R. Wallace and R. Dawson Jr. (1990). Effect of age and monosodium L glutamate treatment on neurotransmitter content in brain regions from male Fischer 344 rats. Neurochem. Res., 15:889-898.
R. Dawson Jr. and D.R. Wallace. (1992) Taurine content in tissues from aged Fischer 344 rats. AGE, 15:73-81.
D.R. Wallace and R. Dawson Jr. (1992). Ammonia regulation of phosphate activated glutaminase displays regional variation and impairment in the brain of aged rats. Neurochem. Res., 17:1113-1122.
R. Dawson Jr. and D.R. Wallace. (1992) Kainic acid induced seizures in aged rats: Neurochemical Correlates. Brain Res. Bull., 29:459-468.
R. Dawson Jr. and D.R. Wallace. (1993) Regulation of phosphate activated glutaminase (PAG) by glutamate analogues. Neurochem. Res., 12:125-132.
D.R. Wallace and R. Dawson Jr. (1993) Regional regulations of phosphate activated glutaminase in rat brain by calcium and phosphate: Impairment in aged rats and implication for the existence of isozymes. Neurochem. Res., 18:1271-1279.
D.R. Wallace, D.T. Muskardin and N.R. Zahniser. (1994) Pharmacological characterization of [3H] idazoxan, [3H] RX821002 and para [125I] iodoclonidine binding to alpha2 adrenoceptors in rat cerebral cortex membranes. Eur. J. Pharmacol., 258:67-76.
D.R. Wallace and R. Dawson Jr. (1994) Effect of the aging process on kinetics and activity of phosphate activated glutaminase from various brain regions of adult and aged Fischer 344 rats. AGE, 17:59-63.
R.M. Booze and D.R. Wallace. (1995) Dopamine D2 and D3 receptors in the rat striatum and nucleus accumbens: Use of 7-OH-DPAT and [125I]Iodosulpride. Synapse, 19:1-13.
D.R. Wallace and R.M. Booze. (1995) Identification of D3 and sigma receptors in the rat striatum and nucleus accumbens using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin and carbetapentane. J. Neurochem., 64:700-710.
D.R. Wallace and R.M. Booze. (1995) Pramipexole, a D3-selective agonist that lacks sigma interactions in the rat brain. Neurosci. Res. Comm. 17:177-183.
D.R. Wallace, C.F. Mactutus and R.M. Booze. (1996) Repeated intravenous cocaine administration: Locomotor activity and dopamine D2/D3 receptors. Synapse 23:152-163.
D.R. Wallace and R.M. Booze. (1996). Dopamine D3 receptor density elevation in aged Fischer-344 X Brown Norway (F1) rats. Eur. J. Pharmacol., 308:283-285.
D.R. Wallace and R.M. Booze. (1997) Upregulation of (+)-7-hydroxy-N,N-di-n-[3H]propylaminotetralin binding following intracerebroventricular administration of a nitric oxide generator. Neurochem. Res. 22:163-170.
R.M. Booze, A.F. Lehner, D.R. Wallace and C.F. Mactutus. (1997) Dose response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized freely moving male rats. Neurotoxicol. Teratol. 19:7-15.
P.C. Bickford, C.E. Adams, S.J. Boyson, P. Curella, G.A. Gerhardt, C. Heron, G.O. Ivy, A.M.L.Y. Lin, M.P. Murphy, K. Poth, D.R. Wallace, D.A. Young, N.R. Zahniser, G.M. Rose. (1997). Long term treatment of male F344 rats with deprenyl: Assessment of effects on longevity, behavior, and brain function. Neurobiol. Aging. 18:309-318.
P. Green, R. Dawson Jr., D.R. Wallace and J. Owens. (1998). Treatment of rat brain membranes with taurine increases radioligand binding. Adv. Exp. Med. Biol. 442:377-383.
D.R. Wallace, J. Owens and R.M. Booze. (1998). [3H](+) 7-OH-DPAT and [3H] Pramipexole binding in the striatum and nucleus accumbens of Sprague-Dawley and Fischer-344 rats. Life Sci. 63:PL275-PL280.
L.C. Newman, D.R. Wallace and C.W. Stevens. (1999) Characterization of [3H]-diprenorphine binding in Rana pipiens: Observations of filter binding enhanced by naltrexone. J. Pharmacol. Toxicol. Meth. 41:43-48.
A.L. Coon, D.R. Wallace and R.M. Booze. (1999) [3H] PN200-110 L-type calcium channel antagonist binding in the hippocampus and cerebellum of Alzheimer’s disease. Neurobiol. Aging. 20:597-603.
D.R. Wallace and R.M. Booze. (2000) Sigma binding sites identified by [3H] DTG are elevated in aged Fischer-344 X Brown-Norway (F1) rats. Synapse. 35:311-313.
L.C. Newman, D.R. Wallace, and C.W. Stevens. (2000) Selective opioid agonist and antagonist displacement of [3H]-Naloxone binding in amphibian brain. Eur. J. Pharmacol. 397:255-262.
L.C. Newman, D.R. Wallace, and C.W. Stevens. (2000) Selective opioid agonist and antagonist competition for [3H] naloxone binding in the amphibian spinal cord. Brain Res. 884:184-191.
L.C. Newman, D.R. Wallace, and C.W. Stevens. (2002) Binding characterization of selective opioids in Rana pipiens brain. J. Pharm. Exp. Therap. 301:364-370.
G.N. Belofsky, A.F. French, D.R. Wallace, and S.L. Dodson (2004) New geranyl stilbenes from Dalea purpurea with in vitro opioid receptor affinity. J.Nat. Prod. 67:26-30.
D.R. Wallace (2005) Overview of Molecular, Cellular and Genetic Neurotoxicology. Neurol Clin. North Amer. 23:307-320.
G.N. Belofsky, D.R. Wallace, and S.L. Dodson (2005) Opioid receptor activity in Tall Grass Prairie plants traditionally used as for analgesia. J. Ethnopharm. (In Press).
D.R. Wallace, S.L. Dodson, A. Nath, and R.M. Booze (2006) Delta opioid agonists attenuate TAT1-72-induced oxidative stress in SK-N-SH cells. Neurotoxicol. 27:101-107.
D.R. Wallace, S. Dodson, A. Nath, and R.M. Booze (2006) Estrogen attenuates gp120- and tat1-72-induced oxidative stress and prevents loss of dopamine transporter function. Synapse. 59:51-60.
J.M. Silvers, D.R. Wallace, S.B. Harrod, C.F. Mactutus, and R.M. Booze (2006) Prenatal cocaine alters dopamine and sigma receptor binding in nucleus accumbens and striatum in dams and offspring. Neurotox. Teratol. 28:173-180.
R.M. Booze, D.R. Wallace, J.M. Silvers, B.J. Strupp, and C.F. Mactutus. (2006) Prenatal cocaine exposure alters alpha-2 receptor expression in adolescent rats. BMC Neuroscience 7:33.
D.R. Wallace. (2006) HIV Neurotoxicity: Mechanisms and potential protective mechanisms. J. Biomed Biotech. 2006:1-10.
Instructional Activities
- Medical Pharmacology - 2nd year medical students
- BIOM 6543 Neurochemistry - Graduate Students
- BIOM 6573 Neurotoxicology - Graduate Students
- BIOM 6553 Neurochemical Basis of Disease - Graduate Students
- VBSC 6200 Biochemical Toxicology - Graduate Students (Stillwater)
- BIOM 6175 Molecular and Cellular Biology - Graduate Students
Research Interests
Laboratory interests focus on the neurotoxic mechanisms of HIV-associated proteins, low-level metal exposure and the development and characterization of neuroactive substances from plants.
Biographical Information
Dr. Wallace joined the University in 1996 after a 4 year fellowship at the University of Kentucky. Since his arrival, Dr. Wallace has been actively involved in teaching 2nd year medical students as well as graduate students in the Biomedical Science Program and the Forensic Science Program. Dr. Wallace has been extensively trained in basic pharmacological methods such as radioligand binding, neurotransmitter uptake/release and intracellular assays. The major foci and interests of the Wallace Laboratory are the excitatory mechanisms underlying neurotoxicity in the Central Nervous System.
