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Mary Bea Drummond | 918-594-8223

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Sean Kennedy | 918-594-8360

Placenta growth factor and diabetes topic of First Friday Seminar

TULSA (Nov. 2, 2011) - Pamela Lloyd, Ph.D., assistant professor of physiological sciences at OSU Center for Veterinary Health Sciences, will discuss “PLGF Expression in Vascular Cells: Effects of Reactive Oxygen Species, Mechanical Stimuli, and Diabetes” at the OSU Center for Health Sciences First Friday Seminar.

The seminar is at noon Friday, Nov. 4, in the Center for Advanced Medical Education, room D-107. Professor William Meek, Ph.D., is seminar host on behalf of the department of anatomy and cell biology. Refreshments are available at 11:45 a.m.

Placenta growth factor (PLGF) is a vascular endothelial growth factor (VEGF)-like growth factor that specifically induces enlargement of pre-existing collateral arteries (unlike VEGF itself, which induces capillary proliferation).

PLGF could be useful in treatment of ischemic cardiovascular disease. However, PLGF has been little-studied compared to VEGF. Dr. Lloyd’s lab is investigating mechanisms regulating PLGF expression in the vasculature, and how those mechanisms may be dysfunctional in diabetes.

“Vessel growth factors such as placenta growth factor and vascular endothelial growth factor regulate the growth of vessels in breast cancer, rheumatoid arthritis, diabetic retinopathy, age-related macular degeneration, and angiosarcoma,” Meek explained.

The seminar is open to the public. Anyone interested in treatments for these diseases that are being explored, investigated and researched, or who wants to know more about how these diseases affect the circulation, is  welcome to attend.

Dr. Lloyd was awarded an R01 research grant by the National Heart, Lung, and Blood Institute of the National Institutes of Health for her project, “Regulation of placenta growth factor by hemodynamics and reactive oxygen species.” The project is investigating the mechanisms controlling the expression of 34PLGF, a protein that contributes to blood vessel growth. This research has important clinical implications because pharmacological modulation of blood vessel growth could potentially be used to treat a wide variety of diseases in both human and veterinary medicine.

The OSU-CHS campus is located at 17th Street and Southwest Boulevard in Tulsa.