Oklahoma State University Center for Health Sciences
Oklahoma State University Center for Health Sciences

Gerwald A. Koehler, Ph.D.


Associate Professor of Microbiology


Education | Professional Experience | Professional Societies | Instructional Activities 
Research Interests| Current Extramural Funding | Representative Publications



Ph.D. (Microbiology)
TU München
Munich, Germany

M.S. (Biology)
TU München
Munich, Germany

Professional Experience

Assistant Professor of Microbiology, Center for Health Sciences, Department of Biochemistry and Microbiology

Assistant Researcher, Department of Cell and Tissue Biology, University of California, San Francisco (UCSF)

Staff Scientist, Research Center for Infectious Diseases, University of Würzburg, Germany

Postdoctoral Fellow, Intercampus Program of Molecular Parasitology, UCSF

Professional Societies

American Dental Education Association (ADEA) 
American Society for Microbiology (ASM)
ASM - Missouri Valley ASM Branch
International Society for Human and Animal Mycology (ISHAM)

Instructional Activities

Medical Microbiology and Immunology (team-taught)
Molecular and Cellular Biology (team-taught)
Microbial Genetics and Genomics
Microbial Pathogenesis

Research Interests

Fungal pathogenesis: Role of lipid metabolism and lipid mediators in fungal infections.

Microbiota-host-pathogen relationship: Elucidation of molecular interactions of beneficial microorganisms with the host and (fungal) pathogens.

Extramural Funding

NIH/NIAID “PGE2 Biosynthesis in Candida albicans” 2007 - 2009
IDeA Network of Biomedical Research Excellence (INBRE) Summer Research Program (Mentor) 2009 - 2012

Representative Publications

Köhler, G. A., S. Assefa, and G. Reid.  2012.  Probiotic interference of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 with the opportunistic fungal pathogen Candida albicans. (In press in Infectious Diseases in Obstetrics and Gynecology, http://www.hindawi.com/journals/idog/aip/636474/).

Glass, R. T., R. S. Conrad, G. A. Köhler, A. J. Warren, and J.W. Bullard.  2011.  Microbiota Found in Protective Athletic Mouthguards.Sports Health: A Multidisciplinary Approach, published online 8 April 2011.

Glass, R. T., R. S. Conrad, G. A. Köhler, and J.W. Bullard.  2011.  Evaluation of the Microbial Flora Found in Woodwinds and Brass Instruments and Their Potential to Transmit Diseases. General Dentistry, online issue March/April 2011.

Glass, R. T., R. S. Conrad, C. R. Wood, A. J. Warren, G. A. Köhler, J.W. Bullard, G. Benson, and J. M. Gulden.  2009.  Protective Athletic Mouth-guards--Do They Cause Harm? Sports Health: A Multidisciplinary Approach, 1: 411-415.

Sroussi, H.Y., Köhler, G.A., Agabian, N., Villines, D., and Palefsky, J.M.  2009.  Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. FEMS immunology and medical microbiology 55: 55-61.

Köhler, G. A., A. Brenot, E. Haas-Stapleton, N. Agabian, R. Deva, and S. Nigam.  2006.  Phospholipase A2 and phospholipase B activities in fungi. BBA – Molecular and Cell Biology of Lipids, 1761: 1391-1399.

Bader, T., K. Schröppel, S. Bentink, N. Agabian, G. Köhler, and J. Morschhäuser.  2006.  Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infection & Immunity 74: 4366-4369.

Theiss, S., G. Ishdorj, A. Brenot, M. Kretschmar, C.-Y. Lan, T. Nichterlein, J. Hacker, S. Nigam, N. Agabian, and G. A. Köhler.  2006.  Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence. International Journal of Medical Microbiology 296: 405-420.

Reid, G., S. O. Kim, and G. A. Köhler.  2006.  Selection, testing and understanding probiotic microbes. FEMS Immunology & Medical Microbiology 46(2): 149-57.

Köhler, G. A., A. Kuo, G. Newport, and N. Agabian.  2006.  Genomics of pathogenic fungi p. 389-416. In: J. Hacker and U. Dobrindt (eds.), Pathogenomics – Genome analysis of pathogenic microbes. Wiley-VCH, Weinheim, Germany.

Braun, B. R., M. van het Hoog, C. d’Enfert, M. Martchenko, J. Dungan, A. Kuo, D. O. Inglis, M. A. Uhl, H. Hogues, M. Berriman, M. Lorenz, A. Levitin, U. Oberholzer, C. Bachewich, D. Harcus, A. Marcil, D. Dignard, T. Iouk, R. Zito, L. Frangeul, F. Tekaia, K. Rutherford, E. Wang, C. A. Munro, S. Bates, N. A. Gow, L. L. Hoyer, G. Köhler, J. Morschhäuser, G. Newport, S. Znaidi, M. Raymond, B. Turcotte, G. Sherlock, M. Costanzo, J. Ihmels, J. Berman, D. Sanglard, N. Agabian, A. P. Mitchell, A. D. Johnson, M. Whiteway, and A. Nantel.  2005.  A Human-Curated Annotation of the Candida albicans Genome. PLoS Genetics 1: 36-57 (e1).

Morschhäuser, J., P. Staib, and G. Köhler.  2005.  CARE-2 Fingerprinting of Candida albicans Isolates, p. 27-34. In E. J. Ernst and P. D. Rogers (ed.), Methods in Molecular Medicine, vol. 118: Antifungal Agents. Humana Press Inc., Totowa, NJ.

Morschhäuser, J., P. Staib, and G. Köhler.  2005.  Targeted gene deletion in Candida albicans wild-type strains by MPAR-flipping, p. 35-43. In E. J. Ernst and P. D. Rogers (ed.), Methods in Molecular Medicine, vol. 118: Antifungal Agents. Humana Press Inc., Totowa, NJ.

Köhler, G. A., X. Gong, S. Bentink, S. Theiss, G. M. Pagani, N. Agabian, and L. Hedstrom.  2005.  The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. J. Biol. Chem. 280: 11295–11302. 

Theiss, S., M. Kretschmar, T. Nichterlein, H. Hof, N. Agabian, J. Hacker, and G. A. Köhler.  2002.  Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence. Molecular Microbiology 43: 571-584.

Theiss, S., G. A. Köhler, M. Kretschmar, T. Nichterlein, and J. Hacker.  2002.  New molecular methods to study gene functions inCandida albicansMycoses 45: 345-350.

Köhler, G., J. Morschhäuser, and J. Hacker.  2002.  Genome structure of pathogenic fungi. Curr Top Microbiol Immunol., 264(II): 149-166.

Wirsching, S., S. Michel, G. Köhler and J. Morschhäuser.  2000.  Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor. J. Bacteriol., 182: 400-404.

Staib, P., S. Michel, G. Köhler and J. Morschhäuser.  2000.  A molecular genetic system for the pathogenic yeast Candida dubliniensis.Gene 242: 393-398.

Staib, P., M. Kretschmar, T. Nichterlein, G. Köhler, and J. Morschhäuser.  2000.  Expression of virulence genes in Candida albicansAdv Exp Med Biol., 485:167-76.

Morschhäuser, J., G. Köhler, W. Ziebuhr, G. Blum-Oehler, U. Dobrindt, and J. Hacker.  2000.  Evolution of microbial pathogens. Philos Trans R Soc Lond B Biol Sci. 355(1397):695-704.

Staib, P., M. Kretschmer, T. Nichterlein, G. Köhler, S. Michel, H. Hof, J. Hacker, and J. Morschhäuser.  1999.  Host-induced, stage-specific virulence gene activation in Candida albicans during infection. Molecular Microbiology 32: 533-546.

Hacker, J., G. Köhler, and J. Morschhäuser.  1999.  Virulence and resistance mechanisms of pathogenic fungi. Nova Acta Leopoldina307: 151-161.

Müller, F.-M., J. Morschhäuser, G. Köhler, T. Oelschlaeger, S. Khan und J. Hacker.  1999.  Adhärenz und Invasion: Zwei Pathomechanismen. Mycoses 42 (Suppl. 1): 39-42.

Hacker, J., G. Blum, G. Köhler, J. Morschhäuser, I. Mühldorfer, and W. Ziebuhr.  1998.  Molecular analysis of infectious diseases: Fungal and bacterial infections of the urinary tract. In: I. Nagataki (ed.). Proceedings of the Siebold Memorial International Symposium.

Köhler, G. A., T. C. White, and N. Agabian.  1997.  Overexpression of a cloned IMP dehydrogenase of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J. Bacteriol. 179: 2331-2338.

Hacker, J., G. Köhler, A. Lischewski, J. Morschhäuser.  1996.  Was können molekulare Methoden in der Mykologie leisten? Med. Report20: 8-9.

Morschhäuser, J., G. Köhler, and J. Hacker.  1996.  Gibt es Pathogenitätsfaktoren bei Pilzen?  Mycoses 39(Suppl. 1): 51-54.

White, T. C., G. A. Köhler, S. H. Miyasaki, and N. Agabian.  1995.  Expression of virulence factors in Candida albicansCanadian J. Bot. 73: S1058-S1064.

Agabian, N., S. H. Miyasaki, G. Köhler, and T. C. White.  1994.  Candidiasis and HIV infection: virulence as an adaptive response.  In: Greenspan, J., (ed).  Oral manifestations of HIV infection.  Quintessence Publishing C., Carol Stream, Illinois, pp. 65-72.

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